Motif ID: TAL1_TCF{3,4,12}.p2

Z-value: 0.463


Transcription factors associated with TAL1_TCF{3,4,12}.p2:

Gene SymbolEntrez IDGene Name
TAL1 6886 T-cell acute lymphocytic leukemia 1
TCF12 6938 transcription factor 12
TCF3 6929 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)
TCF4 6925 transcription factor 4

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
TCF4chr18_-_53255734-0.479.1e-03Click!
TCF3chr19_-_16523270.281.4e-01Click!
TCF12chr15_+_57210889,
chr15_+_57210852,
chr15_+_57210823
-0.271.5e-01Click!
TAL1chr1_-_476954420.251.9e-01Click!


Activity profile for motif TAL1_TCF{3,4,12}.p2.

activity profile for motif TAL1_TCF{3,4,12}.p2


Sorted Z-values histogram for motif TAL1_TCF{3,4,12}.p2

Sorted Z-values for motif TAL1_TCF{3,4,12}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TAL1_TCF{3,4,12}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_-_205391180 1.482 NM_001001552
NM_001199050
NM_001199051
NM_001199052
LEMD1



LEM domain containing 1



chr6_+_86159738 0.967 NT5E
5'-nucleotidase, ecto (CD73)
chr11_+_5410606 0.646 NM_001004756
OR51M1
olfactory receptor, family 51, subfamily M, member 1
chr1_-_153013593 0.621 NM_006945
SPRR2D
small proline-rich protein 2D
chrX_-_46618596 0.614 SLC9A7
solute carrier family 9 (sodium/hydrogen exchanger), member 7
chrX_-_46618471 0.599 NM_032591
SLC9A7
solute carrier family 9 (sodium/hydrogen exchanger), member 7
chr2_-_133539627 0.585 NCKAP5
NCK-associated protein 5
chr5_+_147443534 0.572 NM_001127698
NM_001127699
NM_006846
SPINK5


serine peptidase inhibitor, Kazal type 5


chr21_+_30517897 0.552 C21orf7
chromosome 21 open reading frame 7
chr1_-_17307107 0.540 NM_001135248
NM_002403
MFAP2

microfibrillar-associated protein 2

chr7_-_44105162 0.513 NM_000290
PGAM2
phosphoglycerate mutase 2 (muscle)
chr19_-_11688441 0.485 ACP5
acid phosphatase 5, tartrate resistant
chr8_+_54764367 0.464 NM_170587
RGS20
regulator of G-protein signaling 20
chr11_-_66675334 0.433 NM_022172
PC
pyruvate carboxylase
chr9_+_35673852 0.402 NM_001216
CA9
carbonic anhydrase IX
chr5_+_173472692 0.402 NM_015980
HMP19
HMP19 protein
chr13_-_27334777 0.391 NM_005288
GPR12
G protein-coupled receptor 12
chr2_+_167744996 0.384 NM_001079810
NM_001199143
NM_152381
XIRP2


xin actin-binding repeat containing 2


chr9_+_72658496 0.373 NM_153267
MAMDC2
MAM domain containing 2
chr19_-_11688484 0.347 ACP5
acid phosphatase 5, tartrate resistant
chr10_-_50342052 0.329 NM_001164484
FAM170B
family with sequence similarity 170, member B
chr4_-_20985547 0.322 KCNIP4
Kv channel interacting protein 4
chr6_-_66417069 0.321 NM_001142800
NM_001142801
EYS

eyes shut homolog (Drosophila)

chr20_+_60174816 0.320 NM_001252339
CDH4
cadherin 4, type 1, R-cadherin (retinal)
chr2_-_158300517 0.316 NM_004288
CYTIP
cytohesin 1 interacting protein
chr6_-_163148759 0.314 PARK2
parkinson protein 2, E3 ubiquitin protein ligase (parkin)
chr19_-_51472816 0.303 NM_002774
KLK6
kallikrein-related peptidase 6
chr19_+_15838833 0.300 NM_013939
OR10H2
olfactory receptor, family 10, subfamily H, member 2
chr5_-_176326314 0.295 NM_002115
HK3
hexokinase 3 (white cell)
chr3_-_149095517 0.287 NM_014220
TM4SF1
transmembrane 4 L six family member 1
chr11_-_88796815 0.282 NM_000842
GRM5
glutamate receptor, metabotropic 5
chr6_-_163148798 0.269 PARK2
parkinson protein 2, E3 ubiquitin protein ligase (parkin)
chr10_-_14050453 0.266 FRMD4A
FERM domain containing 4A
chr1_+_36772696 0.266 NM_024676
SH3D21
SH3 domain containing 21
chr22_-_36600759 0.263 NM_030643
NM_145660
APOL4

apolipoprotein L, 4

chr5_-_131879172 0.254 NM_000879
IL5
interleukin 5 (colony-stimulating factor, eosinophil)
chr10_-_73848530 0.253 NM_001244950
SPOCK2
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
chr14_-_94423766 0.253 NM_016150
ASB2
ankyrin repeat and SOCS box containing 2
chr19_-_11688508 0.249 NM_001611
ACP5
acid phosphatase 5, tartrate resistant
chr2_+_33359607 0.242 NM_000627
NM_001166264
NM_001166265
NM_001166266
LTBP1



latent transforming growth factor beta binding protein 1



chr22_+_36649172 0.239 APOL1
apolipoprotein L, 1
chr10_-_73848766 0.238 NM_001134434
NM_014767
SPOCK2

sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2

chr7_+_155437182 0.231 NM_053043
RBM33
RNA binding motif protein 33
chrX_-_15683153 0.229 NM_020665
TMEM27
transmembrane protein 27
chr22_+_31478845 0.219 NM_001207017
SMTN
smoothelin
chr5_+_38403633 0.217 NM_182798
EGFLAM
EGF-like, fibronectin type III and laminin G domains
chr9_+_103204187 0.212 NM_001198812
C9orf30-TMEFF1
C9orf30
C9orf30-TMEFF1 readthrough
chromosome 9 open reading frame 30
chr2_+_108994366 0.212 NM_006588
SULT1C4
sulfotransferase family, cytosolic, 1C, member 4
chr10_+_11206928 0.210 NM_001025076
NM_001083591
CELF2

CUGBP, Elav-like family member 2

chr12_-_2944149 0.208 NM_031474
NRIP2
nuclear receptor interacting protein 2
chr22_+_24979717 0.205 NM_013430
GGT1
gamma-glutamyltransferase 1
chr19_+_17638064 0.204 FAM129C
family with sequence similarity 129, member C
chr5_-_135290521 0.203 NM_002302
LECT2
leukocyte cell-derived chemotaxin 2
chr4_-_152149042 0.202 NM_001243349
SH3D19
SH3 domain containing 19
chr19_-_14889347 0.196 NM_013447
NM_152916
NM_152917
NM_152918
NM_152919
NM_152920
NM_152921
EMR2






egf-like module containing, mucin-like, hormone receptor-like 2






chr6_+_35995583 0.193 MAPK14
mitogen-activated protein kinase 14
chr3_+_133494275 0.192 TF
transferrin
chr16_+_12058963 0.192 NM_001192
TNFRSF17
tumor necrosis factor receptor superfamily, member 17
chr17_+_41003184 0.190 NM_003734
AOC3
amine oxidase, copper containing 3 (vascular adhesion protein 1)
chr3_-_195310770 0.188 APOD
apolipoprotein D
chr12_+_75874512 0.181 NM_006851
GLIPR1
GLI pathogenesis-related 1
chr9_-_85946875 0.179 NM_001244961
FRMD3
FERM domain containing 3
chr8_-_68658577 0.177 NM_020361
CPA6
carboxypeptidase A6
chr7_+_76139744 0.175 NM_030570
NM_182684
UPK3B

uroplakin 3B

chrX_+_16804531 0.171 NM_001168683
NM_018360
TXLNG

taxilin gamma

chr16_+_58010338 0.169 NM_199046
NM_199456
TEPP

testis, prostate and placenta expressed

chr6_-_29323971 0.169 NM_030876
OR5V1
olfactory receptor, family 5, subfamily V, member 1
chr1_-_160681552 0.169 NM_001778
CD48
CD48 molecule
chrX_+_38211735 0.168 NM_000531
OTC
ornithine carbamoyltransferase
chr7_-_41742666 0.166 NM_002192
INHBA
inhibin, beta A
chr7_+_93551015 0.159 NM_004126
GNG11
guanine nucleotide binding protein (G protein), gamma 11
chr6_-_163148800 0.158 NM_004562
NM_013987
NM_013988
PARK2


parkinson protein 2, E3 ubiquitin protein ligase (parkin)


chr19_+_15904760 0.156 NM_001004466
OR10H5
olfactory receptor, family 10, subfamily H, member 5
chr3_-_195310985 0.156 NM_001647
APOD
apolipoprotein D
chr6_-_127780534 0.155 NM_014702
KIAA0408
KIAA0408
chr9_+_116263706 0.151 NM_130795
RGS3
regulator of G-protein signaling 3
chr22_+_36649116 0.151 NM_001136540
NM_001136541
NM_003661
NM_145343
APOL1



apolipoprotein L, 1



chr9_+_12774988 0.150 NM_203403
C9orf150
chromosome 9 open reading frame 150
chr3_-_128186090 0.149 NM_153330
DNAJB8
DnaJ (Hsp40) homolog, subfamily B, member 8
chr10_+_5238756 0.145 NM_001818
AKR1C4
aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)
chr22_+_31489343 0.143 SMTN
smoothelin
chr1_+_32716839 0.142 NM_005356
LCK
lymphocyte-specific protein tyrosine kinase
chr21_-_34185943 0.141 NM_001162495
NM_001162496
NM_019596
C21orf62


chromosome 21 open reading frame 62


chr1_-_93342706 0.141 NM_001252271
FAM69A
family with sequence similarity 69, member A
chr20_+_37209837 0.138 NM_001018082
ADIG
adipogenin
chr9_+_72658735 0.135 MAMDC2
MAM domain containing 2
chr6_-_11382501 0.135 NM_001142393
NEDD9
neural precursor cell expressed, developmentally down-regulated 9
chr1_-_6420719 0.134 NM_181865
ACOT7
acyl-CoA thioesterase 7
chrX_+_69509878 0.134 NM_012310
KIF4A
kinesin family member 4A
chr11_-_71746966 0.133


chr19_+_51760963 0.133 NM_173635
C19orf75
chromosome 19 open reading frame 75
chr19_-_33360641 0.132 NM_001126335
NM_001243036
NM_014270
SLC7A9


solute carrier family 7 (glycoprotein-associated amino acid transporter light chain, bo,+ system), member 9


chr5_+_173472737 0.130 HMP19
HMP19 protein
chr20_-_39766522 0.128


chr22_+_40322609 0.128 GRAP2
GRB2-related adaptor protein 2
chr1_-_207205996 0.127 NM_001083924
NM_023938
C1orf116

chromosome 1 open reading frame 116

chrX_+_103031753 0.126 NM_000533
NM_199478
PLP1

proteolipid protein 1

chr14_-_81864726 0.126 NM_033104
STON2
stonin 2
chr5_-_134782797 0.126 NM_130848
C5orf20
chromosome 5 open reading frame 20
chr5_-_175395544 0.126 NM_032361
THOC3
THO complex 3
chr7_-_76038894 0.125 NM_080744
SRCRB4D
scavenger receptor cysteine rich domain containing, group B (4 domains)
chr13_+_97874704 0.123 MBNL2
muscleblind-like 2 (Drosophila)
chrX_-_69509714 0.122 NM_016484
PDZD11
PDZ domain containing 11
chr15_+_41099254 0.120 NM_001077268
ZFYVE19
zinc finger, FYVE domain containing 19
chr12_-_48119224 0.119 NM_001172439
NM_001172440
NM_006025
ENDOU


endonuclease, polyU-specific


chr1_+_209878135 0.116 NM_005525
HSD11B1
hydroxysteroid (11-beta) dehydrogenase 1
chr4_+_72904848 0.114 NM_001144756
NM_053036
NPFFR2

neuropeptide FF receptor 2

chr1_-_220219853 0.113 EPRS
glutamyl-prolyl-tRNA synthetase
chr11_-_55703875 0.113 NM_006637
OR5I1
olfactory receptor, family 5, subfamily I, member 1
chr12_-_117747214 0.112 NM_001204214
NOS1
nitric oxide synthase 1 (neuronal)
chrX_+_85517970 0.111 NM_001139515
DACH2
dachshund homolog 2 (Drosophila)
chr12_-_123187842 0.107 NM_177551
HCAR2
hydroxycarboxylic acid receptor 2
chr12_-_6745087 0.105 NM_020400
LPAR5
lysophosphatidic acid receptor 5
chr1_+_55013806 0.104 NM_015547
NM_147161
ACOT11

acyl-CoA thioesterase 11

chr2_-_55277698 0.103 NM_020532
NM_153828
NM_207520
RTN4


reticulon 4


chr16_-_28518131 0.103 NM_145659
IL27
interleukin 27
chr17_+_37895023 0.103 NM_001242442
GRB7
growth factor receptor-bound protein 7
chr3_-_10332408 0.102 NM_001134941
NM_016362
GHRL

ghrelin/obestatin prepropeptide

chr17_-_67057046 0.100 NM_080283
ABCA9
ATP-binding cassette, sub-family A (ABC1), member 9
chr1_-_145715561 0.100 NM_007053
CD160
CD160 molecule
chr4_-_24914507 0.096 NM_001130726
CCDC149
coiled-coil domain containing 149
chr7_-_155437056 0.093


chr10_-_121296044 0.091 NM_002925
RGS10
regulator of G-protein signaling 10
chr11_+_72980938 0.091 NM_176798
P2RY6
pyrimidinergic receptor P2Y, G-protein coupled, 6
chr2_-_183903225 0.090 NM_013436
NM_205842
NCKAP1

NCK-associated protein 1

chr22_-_37823503 0.090 NM_052906
ELFN2
extracellular leucine-rich repeat and fibronectin type III domain containing 2
chr10_-_69991854 0.089 NM_145178
ATOH7
atonal homolog 7 (Drosophila)
chr19_+_46195740 0.089 NM_001163377
NM_017659
QPCTL

glutaminyl-peptide cyclotransferase-like

chr1_-_9129666 0.088 NM_001135585
NM_003039
SLC2A5

solute carrier family 2 (facilitated glucose/fructose transporter), member 5

chr15_+_52201590 0.088 TMOD3
tropomodulin 3 (ubiquitous)
chr7_+_18548899 0.086 NM_001204147
NM_001204148
HDAC9

histone deacetylase 9

chr12_-_54778456 0.085 NM_015481
ZNF385A
zinc finger protein 385A
chr20_+_46130600 0.084 NM_001174087
NM_001174088
NM_006534
NM_181659
NCOA3



nuclear receptor coactivator 3



chr14_-_61748510 0.084 NM_001017970
TMEM30B
transmembrane protein 30B
chr21_+_39628869 0.083 NM_170736
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr16_+_89679715 0.083 NM_001128141
DPEP1
dipeptidase 1 (renal)
chr1_-_204165542 0.083 NM_002256
KISS1
KiSS-1 metastasis-suppressor
chr3_+_10068123 0.083 FANCD2
Fanconi anemia, complementation group D2
chr11_-_63684315 0.083 NM_173587
RCOR2
REST corepressor 2
chr2_+_190540710 0.082 NM_144708
ANKAR
ankyrin and armadillo repeat containing
chr7_+_26403944 0.082 NM_001199838
SNX10
sorting nexin 10
chr15_-_74494780 0.082 STRA6
stimulated by retinoic acid gene 6 homolog (mouse)
chr19_-_4302381 0.081 NM_001169126
NM_144615
TMIGD2

transmembrane and immunoglobulin domain containing 2

chr4_-_116034932 0.080 NM_022569
NDST4
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4
chr6_+_31514627 0.079 NM_001144962
NM_001144963
NFKBIL1

nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1

chr9_-_14722669 0.078 NM_005454
CER1
cerberus 1, cysteine knot superfamily, homolog (Xenopus laevis)
chr2_+_219472631 0.078 PLCD4
phospholipase C, delta 4
chr8_-_6783574 0.078 NM_001926
DEFA6
defensin, alpha 6, Paneth cell-specific
chr9_+_131683173 0.077 NM_001100876
NM_174933
PHYHD1

phytanoyl-CoA dioxygenase domain containing 1

chrX_+_152082985 0.076 NM_001178106
NM_001178107
NM_001178108
NM_001178109
NM_001178110
NM_007150
ZNF185





zinc finger protein 185 (LIM domain)





chr4_+_55095263 0.076 NM_006206
PDGFRA
platelet-derived growth factor receptor, alpha polypeptide
chrX_+_128872924 0.075 NM_003399
XPNPEP2
X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound
chr2_+_152214105 0.074 NM_007115
TNFAIP6
tumor necrosis factor, alpha-induced protein 6
chr17_+_75315632 0.074 SEPT9
septin 9
chr12_+_120105656 0.074 NM_006253
PRKAB1
protein kinase, AMP-activated, beta 1 non-catalytic subunit
chr17_-_38657814 0.074 NM_032865
TNS4
tensin 4
chr11_-_6817013 0.073 NM_003696
OR6A2
olfactory receptor, family 6, subfamily A, member 2
chr18_+_56530060 0.073 NM_018181
ZNF532
zinc finger protein 532
chr1_-_177939049 0.072 NM_033127
SEC16B
SEC16 homolog B (S. cerevisiae)
chr1_+_150954498 0.072 NM_003568
ANXA9
annexin A9
chr1_+_86934525 0.071 NM_001285
CLCA1
chloride channel accessory 1
chr17_-_47286742 0.069 NM_031498
NM_001198755
NM_001198756
GNGT2


guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2


chr9_-_104357202 0.069 NM_147180
PPP3R2
protein phosphatase 3, regulatory subunit B, beta
chr7_+_113726490 0.069 FOXP2
forkhead box P2
chrX_-_55057408 0.068 NM_000032
NM_001037967
NM_001037968
ALAS2


aminolevulinate, delta-, synthase 2


chr1_-_201346804 0.067 NM_000364
NM_001001430
NM_001001431
NM_001001432
TNNT2



troponin T type 2 (cardiac)



chr2_+_232457574 0.067 NM_152614
C2orf57
chromosome 2 open reading frame 57
chr15_-_60919642 0.066 NM_002943
NM_134260
RORA

RAR-related orphan receptor A

chr18_+_21572736 0.066 NM_153211
TTC39C
tetratricopeptide repeat domain 39C
chr9_+_124329398 0.066 NM_032552
DAB2IP
DAB2 interacting protein
chr19_+_47840370 0.066 NM_018485
GPR77
G protein-coupled receptor 77
chr2_-_183387063 0.065 NM_005019
NM_001003683
PDE1A

phosphodiesterase 1A, calmodulin-dependent

chr1_+_24840800 0.065 NM_001251980
NM_001251982
NM_001251985
RCAN3


RCAN family member 3


chr7_+_127233688 0.064 NM_020369
FSCN3
fascin homolog 3, actin-bundling protein, testicular (Strongylocentrotus purpuratus)
chr5_-_180627929 0.063 NM_203297
TRIM7
tripartite motif containing 7
chr2_-_55277653 0.063 RTN4
reticulon 4
chr12_-_7848324 0.062 NM_020634
GDF3
growth differentiation factor 3
chr2_+_61404549 0.062 NM_152392
AHSA2
AHA1, activator of heat shock 90kDa protein ATPase homolog 2 (yeast)
chr1_-_220219833 0.061 EPRS
glutamyl-prolyl-tRNA synthetase
chr13_+_97928196 0.061 MBNL2
muscleblind-like 2 (Drosophila)
chr15_+_74900712 0.061 NM_003992
CLK3
CDC-like kinase 3
chrX_+_103031797 0.061 PLP1
proteolipid protein 1
chr6_+_35995513 0.060 MAPK14
mitogen-activated protein kinase 14
chr11_+_113659924 0.059 LOC390251
SH3-domain GRB2-like 1 pseudogene
chr3_+_46919235 0.059 NM_000316
PTH1R
parathyroid hormone 1 receptor
chr14_+_105391154 0.059 PLD4
phospholipase D family, member 4
chrX_+_138612894 0.059 NM_000133
F9
coagulation factor IX
chr2_-_55277459 0.059 RTN4
reticulon 4
chr19_-_14952688 0.058 NM_001005190
OR7A10
olfactory receptor, family 7, subfamily A, member 10
chr12_-_53189780 0.058 NM_057088
KRT3
keratin 3
chr17_+_38119225 0.058 NM_178171
GSDMA
gasdermin A
chr12_+_100750856 0.057 NM_001145288
NM_139319
SLC17A8

solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8

chr2_+_169659099 0.056 NM_001039724
NM_001171632
NM_052946
NOSTRIN


nitric oxide synthase trafficker


chr8_-_80993009 0.056 NM_001025252
TPD52
tumor protein D52
chr2_+_136288953 0.055 NM_015361
R3HDM1
R3H domain containing 1
chr14_+_105391150 0.055 PLD4
phospholipase D family, member 4
chr5_-_112824526 0.054 NM_001085377
MCC
mutated in colorectal cancers
chr1_-_220219874 0.054 NM_004446
EPRS
glutamyl-prolyl-tRNA synthetase
chr1_+_159409511 0.053 NM_012351
OR10J1
olfactory receptor, family 10, subfamily J, member 1
chr8_+_120079423 0.053 NM_006438
COLEC10
collectin sub-family member 10 (C-type lectin)

Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.72 1.83e-03 GO:0005576 extracellular region

Gene overrepresentation in function category:

enrichment   p-value GO term description
8.56 1.77e-02 GO:0008235 metalloexopeptidase activity
7.70 3.27e-02 GO:0003823 antigen binding